Tropical Doctor > Volume 39, Number 4 > Pp. 242-243

This Article Full Text Full Text (PDF) All Versions of this Article: td.2009.090032v1 39/4/242    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Saleem, T. Articles by Jamil, B. PubMed PubMed Citation Social Bookmarking                      What's this?

Case Series and Case Reports

Primary amoebic meningoencephalitis: two new cases from Pakistan

Taimur Saleem MBBS      Madiha Rabbani MBBS     Bushra Jamil MBBS FRCP  

The Aga Khan University, Stadium Road, Karachi, Pakistan

Correspondence to: Taimur Saleem, Room 171, Male Hostel, The Aga Khan University, Stadium Road, Karachi, Pakistan Email: taimur{at}gmail.com

Naegleria fowleri causes a fatal infection of the central nervous system. Only one case of N. fowleri meningoencephalitis has previously been reported from Pakistan. We describe two cases of primary amoebic meningoencephalitis. A 24-year-old man presented with a two-day history of high grade fever, headaches and vomiting. He was put on intrathecal amphotericin B, fluconazole and rifampicin when motile trophozoites were identified on a wet mount of cerebrospinal fluid. The patient did not improve and died on the sixth day of admission. The second case was a 30-year-old man who presented with a three-day history of high grade fever, vomiting and agitation. His clinical course was marked by a rapid deterioration. He received intrathecal amphotericin B, fluconazole and broad spectrum antibiotics when motile trophozoites on wet mount were observed. Again, the patient's condition did not improve and he died on the eighth day of admission.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?