Tropical Doctor > Volume 39, Number 4 > Pp. 223-224

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Clinical features of patients with typhoid fever and drug resistance of the causative isolates in western Iran

Ranjbar Mitra MD   ^*    Mohammad Alizadeh Amir Houshang MD      Hashemi Seyed Hamid MD      Dadashpoor Maryam MD      Madrakian Ali Reza MD      Hadidchi Shima MD      Nojomi Marzieh MD   ^**

^* Department of Infectious Diseases, Iran University of Medical Sciences, Tehran; Department of Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran; Department of Infectious Diseases; Hamedan University of Medical Sciences, Hamedan; ^** Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran

Correspondence to: Ranjbar Mitra, Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran Email: mitraranjbar{at}yahoo.com

Typhoid fever is an important infectious disease in developing countries, including Iran. In this survey, all patients hospitalized in teaching hospitals of Hamedan during 1995–2005 were investigated. A total of 162 patients with typhoid fever were studied. Of all patients, 106 were male (65.4%). The most prevalent symptoms were fever (93.2%), chills (76.5%), anorexia (72.2%) and headache (71%). Splenomegaly and hepatomegaly were present in 43.8% and 13.6%, respectively. Salmonella typhi strains were identified in 144 patients (88.9%) and S. paratyphi A strains were found in 12 (7.4%). In others, S. paratyphi B and C were detected. Serum glutamic oxalo-acetic transaminase values were higher than normal in 77.5% of cases and serum glutamic pyruvic transaminase values were higher than normal in 62.5%. The highest sensitivity rate was for ceftizoxime, 91.4% and the lowest rate was for ampicillin, 16.3%.

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