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Trop Doct 2009;39:223-224
doi:10.1258/td.2009.090046
© 2009 Royal Society of Medicine Press

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Articles

Clinical features of patients with typhoid fever and drug resistance of the causative isolates in western Iran

Ranjbar Mitra MD   *    Mohammad Alizadeh Amir Houshang MD   {dagger}   Hashemi Seyed Hamid MD   {ddagger}   Dadashpoor Maryam MD   §   Madrakian Ali Reza MD   §   Hadidchi Shima MD   §   Nojomi Marzieh MD   **

* Department of Infectious Diseases, Iran University of Medical Sciences, Tehran; {dagger} Department of Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran; {ddagger} Department of Infectious Diseases; § Hamedan University of Medical Sciences, Hamedan; ** Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran

Correspondence to: Ranjbar Mitra, Department of Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran Email: mitraranjbar{at}yahoo.com

Typhoid fever is an important infectious disease in developing countries, including Iran. In this survey, all patients hospitalized in teaching hospitals of Hamedan during 1995–2005 were investigated. A total of 162 patients with typhoid fever were studied. Of all patients, 106 were male (65.4%). The most prevalent symptoms were fever (93.2%), chills (76.5%), anorexia (72.2%) and headache (71%). Splenomegaly and hepatomegaly were present in 43.8% and 13.6%, respectively. Salmonella typhi strains were identified in 144 patients (88.9%) and S. paratyphi A strains were found in 12 (7.4%). In others, S. paratyphi B and C were detected. Serum glutamic oxalo-acetic transaminase values were higher than normal in 77.5% of cases and serum glutamic pyruvic transaminase values were higher than normal in 62.5%. The highest sensitivity rate was for ceftizoxime, 91.4% and the lowest rate was for ampicillin, 16.3%.


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