Tropical Doctor > Volume 37, Number 4 > Pp. 207-210

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Short Reports

Green pit viper (Trimeresurus albolabris and T. macrops) venom antigenaemia and kinetics in humans

Ponlapat Rojnuckarin MD PhD  ¹   Sukit Banjongkit MRCS, MD  ¹   Walee Chantawibun MD  ¹   Benjaporn Akkawat Rsc  ¹   Jumlong Juntiang¹   Jureeporn Noiphrom Msc  ²   Narumol Pakmanee Msc  ²   Tanin Intragumtornchai MD PhD  ¹

¹ Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University;; ² Research and Development Division, Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama IV Road, Bangkok 10330, Thailand

Correspondence to: Ponlapat Rojnuckarin porpiasod{at}hotmail.com

Green pit viper bite is a common public health problem in Southeast Asia. Although most patients experience only local swelling, some may suffer from severe systemic bleeding that can be delayed. Venom antigenaemia was measured by enzyme-linked immunosorbent assay and correlated with clinical findings in 42 patients. Initial venom antigenaemia was not predictive enough for clinical uses. A kinetic study (n = 27) showed highest levels at presentation and, then, progressive decline. The average half-life was 27.5 h during the first three days and over 50 h on days 5-7 after bite. Two small subsets (7.4% each) showed persistently detectable venom on day 14 and a subsequent rise in venom antigenaemia. They were associated with prolonged thrombocytopaenia and coagulopathy, respectively. These data demonstrated the long half-life of the venom, suggesting that waiting for spontaneous resolution of coagulopathy is not preferable. In addition, the delayed venom disappearance, not the initial values, was correlated with haemostatic disorders.

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